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  • Lifespan Neural Dynamics Group
  • Research
  • Team
  • News
  • Publications
  • Software
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  • Lifespan Neural Dynamics Group
  • Research
  • Team
  • News
  • Publications
  • Software
  • Open Positions
  • Social Media
  • Contact
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    • The human brain is remarkably dynamic; we want to know why.

      LIFESPAN NEURAL DYNAMICS GROUP

    • Research

      Housed within the recently established Max Planck UCL Centre for Computational Psychiatry and Ageing Research, the Lifespan Neural Dynamics Group (LNDG) seeks to understand how and why the human brain fluctuates so markedly from moment to moment. In particular, we examine brain signal variability and dynamics in relation to six core research foci (see below): lifespan development, cognition, neuromodulation, structural/functional connectivity, transcranial stimulation, and methods/modelling. Accordingly, we have an inherent multivariate focus that allows the examination of brain signal variability phenomena across multiple levels of analysis. The LNDG is graciously supported by the Max Planck UCL Centre, the Centre for Lifespan Psychology at the MPI for Human Development, and by an Emmy Noether grant from the German Research Foundation (DFG).

      Lifespan Development and Aging

      Degradation of neural dynamics with age

      Early theory on aging, and in particular, the age-based degradation of cognition, is historically ascribed to some form of heightened “neural noise” that interferes with efficient processing (e.g., Crossman & Szafran, 1956; Cremer and Zeef, 1987; Welford, 1965, 1981). However, these early theories had rarely been tested by examining within-subject brain signals directly. Perhaps counterintuitively, our extant in vivo work consistently shows that older, poorer performers may generally exhibit less moment-to-moment brain signal variability than younger, higher performing adults (e.g., Garrett et al., 2010, 2011, JNeurosci; 2013 Cerebral Cortex; 2013 NBR; 2015 PNAS). Overall, our group seeks to understand why healthy, higher performing brains are highly and robustly dynamic across moments (adaptability, dynamic range, multi-stability?), and how this changes with development and aging.

      Cognition

      Behavioral relevance of neural dynamics

      Our interests in the relations between cognition and brain signal variability have been broad to date, spanning simple and complex perceptual decision-making (e.g., Kloosterman et al., 2019, eLife), internal vs. externally modulated states (e.g., Grady and Garrett, 2018, NeuroImage), working (e.g., Garrett et al., 2015, PNAS) and long-term memory (Kloosterman et al., in prep), and reinforcement learning (Skowron et al., in prep) using a variety of stimulus types, cognitive performance metrics, and model parameterizations. Broadly, we find that better performers have higher brain signal variability, and that within-person signal variability can parametrically tune with changes in task difficulty (Garrett et al., 2013a,b, Cerebral Cortex; 2013, NBR; 2015 PNAS). We also continue to examine whether variability may be an expression of the flexible modulation of brain states that allows a probabilistic search for an optimal state, given either unexpected or anticipated changes in the environment (see Garrett et al., 2013, NBR).

      TOM BARRICK / CHRIS CLARK / SGHMS / SCIENCE PHOTO LIBRARY / Universal Images Group

      Structural/Functional Connectivity

      A basis for understanding local dynamics

      It is well known that functional dynamics occur around a static anatomical (white matter) skeleton (Honey et al., 2009). Computational models suggest that realistic network dynamics, and the influence of noise within them, cannot exist without a healthy, biologically plausible WM structure (Deco et al., 2009). However, it remains unknown to what extent the WM skeleton constrains functional dynamics/variability in humans, and across the lifespan. Conversely, although structural connections form the “core skeleton” of brain function, functional connections also exist broadly in absence of direct structural connections (Deco et al., 2009; Ghosh et al., 2008; Honey et al., 2007). Notably, a theoretically and computationally informed contributing factor to brain signal variability effects is that our neural system can explore a broad repertoire of brain states/networks from moment to moment when variability is present (Deco et al., 2009; 2011; Garrett et al., 2013, NBR). Accordingly, a healthy, developed brain (i.e., in young adults) may be more flexible in the face of changing systemic or environmental demands, as it can reconfigure efficiently as required. Assuming that node-based signal variability reflects a dynamic system that is constantly reconfiguring in strength and direction, it is clear that explicitly measuring network-level dynamics is required to determine the bounds of node-based dynamics. We are examining these issues in detail within the LNDG. A recent attempt to link node-wise temporal dynamics to network-level effects (Garrett et al., 2018, NeuroImage) revealed that the vast majority of local temporal variability may be a reflection of network communication/integration rather than local “noise.” Crucially, the thalamus provided a unique and fundamental variability-based signature of how the brain integrates across scales, providing a key anatomical target for future LNDG work probing the generation and mechanisms of temporal variability in the brain.

      Neuromodulation

      Neurochemical bases for neural dynamics

      We are interested in linking theories of dopamine (DA)-based neural “precision” (e.g., Ballo et al., 2012; Coull et al., 2012; Friston, 2010) and dynamics to brain signal variability effects. It is an interesting paradox that signal variability often appears functional for healthy neural systems, yet optimal DA function is presumed to generally invoke tighter bounds on temporal coding. We are currently collaborating with various research groups in Europe to investigate how DA agonists, antagonists, and PET-based DA binding potential may relate to working memory- and reinforcement-learning-based brain signal variability in young and older adults. We find that DA agonism via amphetamine increases BOLD variability in older adults (Garrett et al., 2015, PNAS; see fig above), DA antagonism decreases BOLD variability in younger adults (Garrett et al., in prep), and DA binding (using PET imaging) correlates with BOLD variability in a regionally-dependent manner (Guitart-Masip et al., 2016, Cerebral Cortex; Garrett et al., in prep). DA thus continues to be a primary neurochemical target within the LNDG, with our interests recently expanding to include the norepinephrine (e.g., systemic explore/exploit trade-offs) and glutamate/GABA systems (e.g., state-configuration via excitation/inhibition).

      Transcranial Stimulation

      Boosting deficient dynamics?

      Our initial studies in this domain focus on directly invoking stochastic resonance, which is classically observed when the presence of additive noise allows input signals to be better detected in the brain. Historically, “noise” has been experimentally applied to the nervous system in a number of ways via noisy peripheral visual/tactile/auditory stimuli (e.g., Collins et al., 1996; Wells et al., 2005). However, good evidence for whether/how these peripherally applied “noise” sources reach the brain has been lacking. Alternatively, transcranial noise stimulation methods (tRNS) provide a more direct route to the cortex of the brain, thus piquing our interest in simultaneous tRNS-neuroimaging to examine links between stimulation and brain signal dynamics. Overall, we seek to use tRNS as a “causal” technique for restoring impoverished signal variability levels in older adults.

      Methods/Modeling

      Measures

      We continue to both develop and apply brain signal variability methods, moving beyond general variance measures to ask more explicit questions about the nature of that variance (e.g., spectral content and structure, time delay embedding). We are also inherently interested in discrete patterns in brain signals (e.g., entropy), and how they relate to overall variance (*Grandy, *Garrett et al., 2016). For example, we continue to optimize the estimation of multi-scale entropy that effectively eliminates variance-based biases from computation (Kosciessa et al., in prep; Kloosterman et al., in prep), permitting entropy to be directly compared with oscillatory dynamics within-person (e.g., Kosciessa et al., 2019).

       

      Statistical and computational modeling

      We have a keen interest in multivariate models (e.g., singular value decomposition (SVD)-based techniques) that best enable various correlates of signal dynamics to be simultaneously examined. We are currently exploring how SVD models can be optimized within a mixed-modeling framework in an attempt to link latent-level parametric cognitive performance to parametric task-based brain dynamics (e.g., Garrett et al., 2013 Cereb Cortex; Garrett et al., 2015 PNAS). We also continue to develop whole-to-whole brain multivariate models linking different neuroimaging modalities (e.g., ASL and BOLD; dopamine PET and BOLD; EEG and BOLD; DWI and BOLD; e.g., Garrett et al., 2017, Sci Rep; *Burzynska, *Garrett, et al., 2013, JNeurosci).

       

      We also utilize and develop various computational models of brain and behaviour. For example, we have recently leveraged the HMAX model of the ventral visual cortex to estimate how the complexity of visual input may drive neural variability during perception (Garrett et al., 2018). With regard to behaviour, we have also modelled within-person, reward-driven perceptual decision-making via hierarchical drift diffusion modelling (Kloosterman et al., 2019, eLife), and now deploy various reinforcement-learning models across a host of probabilistic reward-based paradigms.

       

      Software Development

      An important goal of our proposed work is to support the future examination of brain signal variability in neuroimaging through open-source software. At present, no analysis package provides for a comprehensive brain signal variability analysis. As such, we continue to develop an event-related and block-design fMRI-based Variability Toolbox (VarTbx) for SPM. Mimicking a Level-1 analysis, our toolbox allows SPM users (or more generally, Matlab users) to import any preprocessed fMRI data, choose from a number of different variability measures, and to output resulting individual maps for further analysis within SPM’s standard Level-2 module (or elsewhere). The first version of VarTbx is now available; see our software page for details. We further support open science by making all code/algorithms freely available on our LNDG Github repository (https://github.com/LNDG).

    • Team

      The LNDG brain trust

      Douglas D. Garrett, Ph.D.

      Principal Investigator/Senior SCientist

      Prior to heading the Lifespan Neural Dynamics Group (LNDG) within the Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Doug completed degrees at the University of Victoria (BA) and University of Toronto (MA/Ph.D., 2011). He was also a Fellow with the MPS-UCL Initiative for Computational Psychiatry and Ageing Research (2011-2013), and a Research Scientist/Project Leader for the Intra-Person Neural Dynamics Project at the Center for Lifespan Psychology, Max Planck Institute for Human Development in Berlin, Germany. Outside of the lab, you’ll find Doug on a mountain, playing guitar or hockey, running with his dog Baley, or running in-house twin studies with his twin boys :-) CV  Google Scholar

      Niels Kloosterman

      Postdoctoral fellow

      Niels joined the lab in September 2015, after completing his PhD in cognitive neuroscience and a postdoc position with Prof. Tobias Donner at the University of Amsterdam. He is interested in the brain processes that underlie our perceptual experience and that enable us to select sensible courses of action. Within the lab, he focuses on the role of neural variability in perception and decision making, as well as how and why this variability changes with age. Outside of the lab, Niels likes to hang out with his family, listen to electronic music, and play football and tennis. His personal site is here.

      Julian Kociessa

      postdoctoral fellow

      Julian joined the LNDG in October 2016 as a doctoral student in the IMPRS COMP2PSYCH program after obtaining degrees from Freie Universität Berlin (B.Sc. Psychology, 2014) and Humboldt University of Berlin (MSc Mind & Brain, 2016). He has been an LNDG postdoctoral fellow since defending his thesis “Measurement and relevance of rhythmic and aperiodic human brain dynamics” (https://edoc.hu-berlin.de/handle/18452/22780) in 2020. Julian studies how macroscopic human brain dynamics afford and constrain an individual’s perception, cognition and behavior, as well as the flexible adjustment thereof in the face of changing demands. His work includes advances in the measurement of time-varying brain dynamics, such as neural rhythms and signal irregularity. In his work, Julian uses an array of techniques, including computational modeling of behavior, electroencephalography (EEG), structural and functional magnetic resonance imaging (s/fMRI) and pupillometry. 

      Google Scholar Website

      Kristoffer Månsson

      postdoctoral fellow

      Kristoffer received his PhD in clinical psychology in 2016 after defending his thesis Restructuring the Socially Anxious Brain. He joined the LNDG in September 2019 via an international postdoc grant from the Swedish Research Council. Kristoffer is also the study director for the Psychiatry Research School at Karolinska Institutet (Stockholm, Sweden), and regularly teaches cognitive behavioural therapy (CBT)-related techniques. Kristoffer’s research interests incorporate a variety of neuroscientific methods, aiming to better understand the neurobiology and treatment of mental illness (e.g., by examining changes in telomere biology and cellular protection after social anxiety patients received CBT). Kristoffer joined the group to investigate brain signal variability as a predictor of treatment outcome in common psychiatric disorders. Google Scholar 

      Leo Waschke

      Postdoctoral fellow

      After completing his PhD with Jonas Obleser at the University of Lübeck, Leo joined the lab in January 2020. Leo is interested in the dynamic properties of brain activity and how they link to perception and action. He is convinced that in order to understand how the brain enables individuals to perform in a highly adaptive manner, one should focus on the temporal and spatial dynamics of brain activity, including their intra- and inter-individual differences. In his spare time Leo enjoys all things aesthetically pleasing, playing the Saxophone (too rarely), and a good workout. Google Scholar

      Liliana Polyanska

      ph.d. student

      Liliana joined the LNDG lab as a research assistant in 2017, and started her PhD in the COMP2PSYCH program in October 2018. She’ received a BSc degree in Psychology from Humboldt University and is currently doing her master’s in Social, Cognitive and Affective Neuroscience at Freie Unversity Berlin. She is writing her master's thesis in Hugo Critchley’s group at the Sackler Centre for Consciousness Science, University of Sussex on the topic of emotion perception in Tourette syndrome. Liliana is interested in brain network dynamics and the influence of emotions and stress on people’s judgement and behavior. In her future work, she would like to combine neurocognitive and computational methods.

      Alexander Skowron

      PhD student

      Alex joined the lab in 2017 as an intern/master's student, and began house PhD in October 2019. He obtained his Bachelor’s degree in Psychology from Leiden University and his master's in the Social, Cognitive and Affective Neuroscience Master's program at Freie Universität Berlin. Alex is particularly interested in multimodal brain-signal variability and entropy metrics in the context of learning and memory. He is a member of both the LIFE and COMP2PSYCH graduate programs. In his free time, he enjoys participating in Uni sports and playing video games.

      Fabian Kamp

      Research assistant

      Fabian studies Social, cognitive and affective Neuroscience (MSc) at the FU, and joined the LNDG in January 2020. He is currently writing his master thesis at the Technical University Berlin on the topic of structural/functional connectivity in schizophrenia. He is particularly interested in computational psychiatry, brain simulations, and neuroplasticity. In his free time, Fabian enjoys traveling - especially to Italy.

      Alireza Tarikhi

      Research assistant

      Alireza recently joined the group to work on brain stimulation. He finished his Master's of clinical psychology at Tehran University of Medical Sciences. He brings his EEG background (and experience on heart rate variability across the lifespan, as a collaborator with the MindBrainBody institute) to investigate neural variability with the LNDG. His research interests are focused on the underlying neural dynamics resulting from noise stimulation, and their influence on perception/cognition (potentially invoking stochastic resonance). In his spare time, he enjoys classic forms of painting and woodworking.

      Laura Terlau

      Research assistant

      Laura joined the LNDG in June 2020 and recently started the social, cognitive and affective neuroscience Master’s program at the FU Berlin. She is broadly interested in the neural representations underlying memory, learning and social cognition, as well as how these representations vary across individuals. She is aiming to combine naturalistic paradigms with neurocognitive and computational methods. Within the lab she focuses on the role of brain signal variability in perception and how it’s linked to ageing as well as memory. Outside of the institute, Laura can be found at AcroYoga sessions, biking around the city, hiking or surfing.

      LNDG Collaborators

      Lars Bäckman (Aging Research Center, Karolinska Institute)

      Cheryl Grady (Rotman Research Institute, Baycrest; University of Toronto)

      Marc Guitart-Masip (Aging Research Center, Karolinska Institute)

      Hauke Heekeren (Free University Berlin)

      Ulman Lindenberger (MPI for Human Development)

      Stu MacDonald (University of Victoria)

      Randy McIntosh (Rotman Research Institute, Baycrest; University of Toronto)

      Lars Nyberg (Umeå University)

      Rafael Polania (University of Zurich)

      Thad Polk (University of Michigan)

      Naftali Raz (Wayne State University)

      Christian Ruff (University of Zurich)

      Alireza Salami (Aging Research Center, Karolinska Institute)

      Greg Samanez-Larkin (Duke)

      LNDG Alumni

      Aidan Brinda (intern)

      Vivien Chopurian (research assistant)

      Cristiana Dimulescu (master's student)

      Samira Epp (master's student)

      Elisabeth Höhne (intern)

      Matthias Kerkemeyer (intern)

      Lanfang Liu (visiting Ph.D. student)

      Janina Marchner (research assistant)

      Alistair Perry (postdoc)

      Sarah Polk (research assistant)

      José Yordan Ramirez (research assistant)

      Neslihan Sener (master's student)

      Stefan Schmidt (programmer)

      Marija Tochasde (master's student)

      Evi van den Elzen (master's student)

      Patrick Werner (research assistant

      Iris Wiegand (postdoctoral fellow)

      Steffen Wiegert (lab manager)

    • News

      The latest from LNDG

      Now out in eLife: How modulation of neural entropy may drive decision biases
      August 4, 2020
      Adopting particular decision biases allows organisms to tailor their choices to environmental...
      New paper in Cerebral Cortex on parametric shifts in functional connectivity in young and older adults
      June 29, 2020
      Degrading face stimuli reduces face discrimination in both young and older adults, but the brain...
      New preprint on the key role of thalamus in adjusting "excitability" in the human brain
      June 23, 2020
      Adaptive human behavior builds on prior knowledge about stimulus relevance. Some environments cue...
      New paper in PLOS Computational Biology on issues with estimating entropy in neural signals
      May 11, 2020
      Multiscale Entropy (MSE) is used to characterize the temporal irregularity of neural time series...
      New paper in NeuroImage on how brain signal variability "mirrors" stimulus complexity in higher performing older adults
      April 10, 2020
      The extent to which brain responses differ across varying cognitive demands is referred to as ...
      New paper out in NeuroImage on neural rhythm detection
      February 1, 2020
      The average power of rhythmic neural responses as captured by MEG/EEG/LFP recordings is a...
      More Posts
    • Publications

      Our work

      Manuscripts under review

      Månsson, K.N.T., Waschke, L., Manzourid, A., Furmark, T., Fischer, H., & Garrett, D.D. (under review). Moment-to-moment brain signal variability reliably predicts psychiatric treatment outcome. 

       

      Garrett, D.D., Skowron, A., Wiegert, S., Adolf, J., Dahle, C.L., Lindenberger, U., & Raz, N. (under review). Losses in brain signal variability and functional integration are coupled with declines in cognitive performance over two years.

       

      Lalwani, P., Garrett, D.D., & Polk, T. (under review). Dynamic recovery: GABA agonism restores neural variability in older, poorer performing adults​.

       

      Waschke, L., Donoghue, T., Fiedler, L., Smith, S., Garrett, D.D., Voytek, B., & Obleser, J. (under review). Modality-specific tracking of attention and sensory statistics in the human electrophysiological spectral exponent. bioRxiv. Link

      Peer reviewed articles

      Kosciessa, J.Q., Lindenberger, U., & Garrett, D.D. (in press). Thalamocortical excitability adjustments guide human perception under uncertainty. Nature Communications. Link

       

      Waschke, L., Kloosterman, N., *Obleser, J., & *Garrett, D.D. (2021). Behaviour needs neural variability. Neuron, 109, 1-16. Link

       

      Kloosterman, N.A., Kosciessa, J.Q., Lindenberger, U., Fahrenfort, J.J., & Garrett, D.D. (2020). Boosts in brain signal variability track liberal shifts in decision bias. eLife, 9:e54201. Link

       

      Grady, C.L., Nichol, D., Rieck, J., & Garrett, D.D. (2020). Whole brain functional connectivity and representational similarity within the Face Network contribute to reduced discrimination of degraded faces in young and older adults. Cerebral Cortex, 10.1093/cercor/bhaa179. Link

       

      Kosciessa, J.Q., Kloosterman, N.A., & Garrett, D.D. (2020). Standard multiscale entropy reflects neural dynamics at mismatched temporal scales: What’s signal irregularity got to do with it? PLOS Computational Biology: 16(5): e1007885. Link

       

      Garrett, D.D., Epp, S.M., Kleemeyer, M., Lindenberger, U., and Polk, T.A. (2020). Higher performing older adults upregulate brain signal variability in response to feature-rich sensory input. NeuroImage. Link

       

      Kosciessa, J.Q., Grandy, T.H., Garrett, D.D., & Werkle-Bergner, M, (2020). Single-trial characterization of neural rhythms: potential and challenges. NeuroImage. Link

       

      Liu, L., Zhang, Y., Zhou, Q., Garrett, D.D. Lu, C., Chen, A., Qiu, J., Ding, G. (2020). Auditory-Articulatory Neural Coupling between Listener and Speaker during Verbal Communication. Cerebral Cortex. doi: 10.1093/cercor/bhz138. Link

       

      Kloosterman, N.A., de Gee, J.W., Werkle-Bergner, M., Lindenberger, U., *Garrett, D.D., *Fahrenfort, J.J. (2019). Humans strategically shift decision bias by flexibly adjusting sensory evidence accumulation. eLife, 8:e37321. Link 

       

      Salami, A., Garrett, D.D., Rieckmann, A., Wåhlin, A., Papenberg, G., Karalija, N., Andersson, M., Axelsson, J.,Johansson, J., Riklund, K., Lövdén, M., Lindenberger, U., Bäckman, L., & Nyberg, L. (2019). Dopamine D2 binding potential modulates neural signatures of working memory in a load-dependent fashion. Journal of Neuroscience, 39, 537-547. Link

       

      Garrett, D.D., Epp, S., Perry, A., & Lindenberger, U. (2018). Local variability reflects lower dimensional functional integration in the human brain. NeuroImage, 183, 776-787. Link preprint

       

      Salami, A., Rieckmann, A., Karalija, N., Avelar-Pereira, B., Andersson, M., Wåhlin, A., Papenberg, G., Garrett, D.D., Riklund, K., Lövdén, M., Lindenberger, U., Bäckman, L., & Nyberg, L. (2018). Neurocognitive profiles of healthy older adults with working-memory dysfunction. Cerebral Cortex, 28, 2525–2539. Link

       

      Grady, C.L. & Garrett, D.D. (2018). Brain Signal Variability is Modulated as a Function of Internal and External Demand in Younger and Older Adults. NeuroImage, 169, 510-523. Link

       

      Halliday, D., Mulligan, B., Garrett, D.D., Schmidt, S., Hundza, S., Garcia-Barrera, M., Stawski, R., MacDonald, S.W.S. (2018). Mean and Variability In Functional Brain Activations Differentially Predict Executive Function in Older Adults: A Novel Investigation Employing Functional Near Infrared Spectroscopy. Neurophotonics, 5, 011013, doi: 10.1117/1.NPh.5.1.011013. Link

       

      Lövdén, M., Karalija, N., Andersson, M., Wåhlin, A., Axelsson, J., Köhncke, Y., Jonasson, L.S., Rieckmann, A., Papenberg, G., Garrett, D.D., Guitart-Masip, M., Salami, A., Riklund, K., Bäckman, L., Nyberg, L., & Lindenberger, U. ( 2017). Latent-Profile Analysis Reveals Behavioral and Brain Correlates of Dopamine-Cognition Associations. Cerebral Cortex, doi.org/10.1093/cercor/bhx253. Link


      Garrett, D.D., Lindenberger, U., Hoge, R., and Gauthier, C.J. (2017). Age differences in brain signal variability are robust to multiple vascular controls. Scientific Reports, 7, 10149. Link

       

      Nyberg, L., Karaljia, N., Salami, A., Andersson, M., Wåhlin, A., Kaboovand, N., Axelsson, J., Rieckmann, A., Papenberg, G., Garrett, D.D., Ricklund, K., Lövden, M., Lindeberger, U., Köhncke, Y., and Bäckman, L. (2016). Dopamine D2 receptor availability is linked to striato-hippocampal functional connectivity and episodic memory. Proceedings of the National Academy of Sciences of the United States of America, 113, 7918-7923. Link

       

      *Grandy, T., *Garrett, D.D., Schmiedek, F., and Werkle-Bergner, M. (2016). On the estimation of brain signal entropy from sparse neuroimaging data. Scientific Reports, 6, 23073. Link

       

      Guitart-Masip, M., Salemi, A., Garrett, D.D., Rieckmann, A., Lindenberger, U., & Bäckman, L. (2016). BOLD variability is related to dopaminergic transmission and cognitive aging. Cerebral Cortex, 26, 2074–2083 . Link

       

      Garrett, D.D., Nagel, I.E., Preuschhof, C., Burzynska, A.Z., Marchner, J., Wiegert, S., Jungehülsing, G., Nyberg, L., Villringer, A., Li, S-C., Heekeren, H.E., Bäckman, L., & Lindenberger, U. (2015). Amphetamine modulates brain signal variability and working memory in younger and older adults. Proceedings of the National Academy of Sciences of the United States of America, 112, 7593-7598. Link

       

      Garrett, D.D., McIntosh, A.R., & Grady, C.L. (2014). Brain signal variability is parametrically modifiable. Cerebral Cortex, 24, 2931-2940. Link

       

      Grady, C.L. & Garrett, D.D. (2013). Understanding variability in the BOLD signal and why it matters for aging. Brain Imaging and Behavior, doi: 10.1007/s11682-013-9253-0. Link

       

      *Burzynska, A.Z., *Garrett, D.D., Preuschhof, C., Nagel, I.E., Li, S-C., Bäckman, L., Heekeren, H.E., & Lindenberger, U. (2013). A scaffold for efficiency in the human brain. Journal of Neuroscience, 33, 17150-17159. Link

       

      Garrett, D.D., Samanez-Larkin, G.L., MacDonald, S.W.S., Lindenberger, U., McIntosh, A.R., & Grady, C.L. (2013). Moment-to-moment brain signal variability: A next frontier in brain mapping? Neuroscience & Biobehavioral Reviews, 37, 610-624. Link

       

      Garrett, D.D., Kovacevic, N., McIntosh, A.R., & Grady, C.L. (2013). The modulation of BOLD variability between cognitive states varies by age and processing speed. Cerebral Cortex, 23, 684-693. Link

       

      Garrett, D.D., MacDonald, S.W.S., & Craik, F.I.M. (2012). Intraindividual reaction time variability is malleable: Feedback- and cognitive reserve-related reductions in variability with age. Frontiers in Human Neuroscience, 6, 101. doi: 10.3389/fnhum.2012.00101. Link

       

      Garrett, D.D., Kovacevic, N., McIntosh, A.R., & Grady, C.L. (2011). The importance of being variable. Journal of Neuroscience, 31, 4496-4503. Link

       

      Garrett, D.D., Kovacevic, N., McIntosh, A.R. & Grady, C.L. (2010). Blood oxygen level-dependent signal variability is more than just noise. Journal of Neuroscience, 30, 4914-4921. Link

       

      Garrett, D.D., Grady, C.L., & Hasher, L. (2010). Everyday memory compensation: The impact of cognitive reserve, subjective memory, and stress. Psychology and Aging, 25, 74-83. Link

       

      McIntosh, A.R., Kovacevic, N., Lippe, S, Garrett, D.D., Grady, C.L., & Jirsa, V. (2010). The development of a noisy brain. Archives of Italian Biology, 148, 323-337. Link

       

      Lindstrom-Forneri, W., Tuokko, H., Garrett, D.D., & Molnar, F. (2010). Everyday competence: Theories, measurement strategies, and its relations to driving. Clinical Gerontologist, 33, 283-297. Link

       

      Garrett, D.D., Tuokko, H., & Stajduhar, K. (2008). Planning for end-of-life care: Findings from the Canadian Study of Health and Aging. Canadian Journal on Aging, 27, 11-21. Link

       

      Stepaniuk, J.A., Tuokko, H.A., McGee, P., Garrett, D.D. & Benner, E.L. (2008). Impact of transit training and free bus pass on public transportation use by older drivers. Preventative Medicine, 47, 335-337. Link

       

      Dixon, R.A., Garrett, D.D., Lentz, T.L., Strauss, E., & Hultsch, D.F. (2007). Neurocognitive markers of mild cognitive impairment: Exploring the roles of speed and inconsistency. Neuropsychology, 21, 381-399. Link

       

      Tuokko, H., Garrett, D.D., McDowell, I., Silverberg, N., & Kristjansson, B. (2003). Cognitive decline in high-functioning older adults: Reserve or ascertainment bias? Aging and Mental Health, 7, 259-270. Link

      Chapters and Commentaries

      Garrett, D.D., McIntosh, A.R., & Grady, C.L. (2011). Moment-to-moment brain signal variability can inform models of stochastic facilitation now. Nature Reviews Neuroscience, 12, 612. Link

       

      Garrett, D.D., Kovacevic, N., McIntosh, A.R. & Grady, C.L., (2010). All within-subject BOLD standard deviations are not created equal [response to Mohr, P.N. & Nagel, I.E.]. Journal of Neuroscience, 30, 7755-7757. [doi:10.1523/JNEUROSCI.1560-10.2010]. Link

       

      Dixon, R.A., Garrett, D.D., & Backman, L. (2008). Compensation in cognitive neurorehabilitation. In D.T. Stuss, G. Winocur and I.H. Robertson (Eds.), Cognitive Neurorehabilitation, 2nd Edition. Cambridge: Cambridge University Press. Link

      Other contributions

      Garrett, D.D. (2018). If you want to be a scientist parent, come to Germany. eLife. Link

       

      Garrett, D.D. & Grady, C.L. (2010). Review of Stephens et al. (2010). Faculty of 1000, Dec, 2010.

       

      Garrett, D.D. & Grady, C.L. (2010). Review of Gazzaniga (2010). Faculty of 1000, Aug, 2010.

    • Software

      Openly available tools and algorithms developed by LNDG

      Variability Toolbox

      for SPM

      (VarTbx)

      https://github.com/LNDG/vartbx

      VarTbx measures within-voxel time series variability in fMRI data. The VarTbx structure is intended to be similar to a standard SPM first-level analysis. You can then proceed to pass those first-level, variability-based images to a level-2 SPM analysis in order to model group effects of interest. However, the first-level NIFTI output files could also be used within other statistics programs of your choice (e.g., FSL, AFNI, PLS).

       

      VarTbx currently supports modeling block designs with a boxcar model, and computes temporal variability using measures such as: detrended variance (VAR), detrended standard deviation (SD), mean squared successive difference (MSSD), and SQRT(MSSD). We plan to add additional modeling approaches and variability measures in future releases.

       

      Using VarTbx is relatively straightforward. You first specify your first-level SPM model, as usual. You then save the model, which is used as input to specify all sessions, conditions, onsets, durations, and nuisance regressors for VarTbx. Finally, after choosing a variability metric of interest, variability-based NIFTI images are then produced. Click on the video above for a short VarTbx tutorial.

      Extended

      Better Oscillation 

      Detection (eBOSC)

      https://github.com/LNDG/eBOSC

      The average power of rhythmic neural responses as captured by MEG/EEG/LFP recordings is a prevalent index of human brain function. Increasing evidence questions the utility of trial-/group averaged power estimates however, as seemingly sustained activity patterns may be brought about by time-varying transient signals in each single trial. Hence, it is crucial to accurately describe the duration and power of rhythmic and arrhythmic neural responses on the single trial-level.

       

      In a recently published paper (Kosciessa et al., 2019, NeuroImage), we extended an existing rhythm detection algorithm (extended Better OSCillation detection: “eBOSC”) to systematically investigate boundary conditions for estimating neural rhythms at the single-trial level.

       

      The eBOSC package is now freely available on Github.

      Modified

      multiscale entropy (mMSE)

      https://github.com/LNDG/mMSE

      Recently, we have developed a novel algorithm based on multiscale entropy (Costa et al. 2002) called modified multiscale entropy (mMSE) that directly quantifies the temporal irregularity of time-domain EEG/MEG/LFP signals at longer and shorter timescales. In general, patterns of fluctuations in brain activity that tend to repeat over time are assigned lower entropy, whereas more irregular, non-repeating patterns yield higher entropy. To allow the investigation of dynamic changes in signal irregularity, we developed mMSE as a time-resolved variant, while also permitting assessment of entropy over atypically longer time scales by calculating across discontinuous, concatenated segments.

       

      For further details, see:

       

      Kloosterman NA, Kosciessa J, Lindenberger U, Fahrenfort J, Garrett DD (2019) Boosting Brain Signal Variability Underlies Liberal Shifts in Decision Bias. Biorxiv:834614. Link

       

      Kosciessa JQ, Kloosterman NA, Garrett DD (2020) Standard multiscale entropy reflects neural dynamics at mismatched temporal scales: What’s signal irregularity got to do with it? PLOS Computational Biology: 16(5): e1007885. Link

       

      And for a FieldTrip tutorial and implementation, click here

    • Open Positions

      Work within the LNDG

      Left to right: Alexander Skowron, Steffen Wiegert, Liliana Polyanska, Douglas Garrett, Alistair Perry,

      Julian Kosciessa, Niels Kloosterman, Alireza Tarikhi, Marija Tochadse, José Yordán Ramirez, Sarah Polk

      Postdoctoral positions

      We continue to recruit excellent postdoctoral fellows, with no fixed deadline for applications or expression of interest.

       

      Ph.D. positions

      Since 2016, an International Max Planck Research School (Ph.D. level) on computational methods (IMPRS COMP2PSYCH) has been funded, in association with the Max Planck UCL Centre for Computational Psychiatry and Ageing Research. The annual application deadline for positions is typically in late Winter each year.

       

      Student assistant/Master's thesis student positions

      Several student assistant positions may be available in LNDG at any one time, depending on the studies we are currently running. Many student assistants also formulate and complete their master's thesis while employed.  

       

      Internships

      Three-month paid internships are also possible within LNDG. There is no specific structure to such an internship, but is typified by students acquiring a specific technique and/or helping with a specific study.   

       

      Regarding all available positions, please email us directly at lndg -at- mpib-berlin.mpg.de.

    • Social Media

      Connect with LNDG

    • Contact the Lifespan Neural Dynamics Group

      We welcome any questions or comments you have. Please contact us at:


      Max Planck UCL Centre for Computational Psychiatry and Ageing Research

       

      Berlin

      Max Planck Institute for Human Development

      Lentzeallee 94
      14195 Berlin, Germany

       

      Email: lndg@mpib-berlin.mpg.de

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